Pancreatic Cancer Clinical Trials and the Role of Oncoshot 

Ongoing Pancreatic Cancer Research provides new directions of Hope and Possibility to thousands of Pancreatic Cancer Patients around the world. There are more than a thousand Pancreatic Cancer Clinical Trial options, at any given point in time, all over the world. Through these Trials, patients can get access to new and advanced Treatments years before they are available as Standard Treatments. International Pancreatic Cancer Treatment Guidelines recommend participating in Clinical Trials to improve the Patient’s Prognosis. [Reference: Cancer of the Pancreas: ESMO Clinical Practice Guidelines]

Oncoshot’s Mission is to simplify the Cancer Clinical Trial landscape for all Cancer types and help patients explore Global Trial options, within a single online resource. Our advanced Search and Match tool will help you find the Pancreatic Cancer Clinical Trial options that match your particular Cancer case.


Pancreatic Cancer Clinical Trials 

The following section provides a snapshot view of the number of clinical trial options (estimated on 11 March 2019, from www.clinicaltrials.gov) for Pancreatic Cancer. 

There are close to a thousand active Clinical Trials for Pancreatic Cancer across the world. 

Phase I: There are more than two hundred active Clinical Trials for Pancreatic Cancer across the world. 

Phase II: There are more than three hundred active Clinical Trials for Pancreatic Cancer across the world. 

Phase III: There are close to fifty active Clinical Trials for Pancreatic Cancer across the world. 

Phase IV: There are around ten active Clinical Trials for Pancreatic Cancer across the world.  


TYPES OF PANCREATIC CANCER TRIALS


Early Diagnosis & Screening Trials for Pancreatic Cancer 

Methods for Early Diagnosis and to improve the understanding of the Causative Mechanisms leading to Pancreatic Cancer is a major focus of Clinical Trials. There are more than a hundred active Clinical Trials for Screening and Diagnostic methods for Pancreatic Cancer across the world. 

Following are some of the significant interventions being studied: 

  1. 1.Genetic testing for mutations in KRAS, BRCA2, p16, p53 
  2. New Molecular Biomarkers 
  3. 3.Advancements in Endoscopic Ultrasound (EUS), ERCP (Endoscopic Retrograde Cholangiopancreatography) 
  4. 4.Screening for Risk Factors 

Laparoscopic Surgery Trials for Pancreatic Cancer 

Improvement in the Surgery technique for effective removal of resectable Pancreatic Cancer is a focus area in Pancreatic Cancer Clinical Trials across the world today. Late detection and rapid progress of Pancreatic Cancer poses several challenges for effective Surgical Resection. Clinical trials are ongoing to develop more advanced and effective techniques for appropriate and adequate removal of the tumour mass. Laparoscopic Surgery is one technique being evaluated in Clinical Trials. 

There are close to ten active Clinical Trials for evaluating Surgical methods for Pancreatic Cancer across the world. 

 Radiation Therapy Trials for Pancreatic Cancer 

Late detection, rapid progress and poor prognosis of Pancreatic Cancer mean that many patients are in Advanced Stages of Cancer at diagnosis. Advanced stages can yield to a combination of Radiation therapy in some form with other Chemotherapy options. Traditional Radiation therapy has its limitations in the efficacy against Pancreatic Cancer. There are more than a hundred active Clinical Trials for evaluating Radiation therapy methods for Pancreatic Cancer across the world. 

Following are some of the significant techniques being studied: 

  1. 1.Stereotactic Radiation 
  2. MRI Guided On-table Adaptive Radiation 
  3. Proton Beam Radiation 

Chemotherapy Trials for Pancreatic Cancer 

Late detection, rapid progress and poor prognosis of Pancreatic Cancer mean that many patients are in Advanced Stages of Cancer at diagnosis. Advanced stages can yield to a combination of Systemic Chemotherapy options. Traditional Chemotherapy has its limitations in the efficacy against Pancreatic Cancer. There are more than two hundred active Clinical Trials for evaluating innovative Chemotherapy methods for Pancreatic Cancer across the world. 

Following are some of the significant interventions being studied: 

  1. 1.Innovative approaches to standard Chemotherapy agents like Gemcitabine (Gemzar), 5-fluorouracil (5-FU), Oxaliplatin (Eloxatin), Albumin-bound paclitaxel (Abraxane), Capecitabine (Xeloda), Cisplatin, Irinotecan (Camptosar)
  2. Innovative approaches to Combination Chemotherapy + Radiation 
  3. Innovative approaches to Combination Chemotherapy + Innovative Immunotherapy or Targeted Therapy 

Immunotherapy - Checkpoint Inhibitor Trials for Pancreatic Cancer 

Immune Checkpoint Inhibitors are a class of drugs that are developed to block the Immune Checkpoints so that the Immune System can act against the Cancer cells. The common types of Immune Checkpoint Inhibitors are the ones inhibiting the PD-1, PD-L1 or the CTLA-4 pathways. There are around fifteen active Clinical Trials for evaluating innovative Checkpoint Inhibitors for Pancreatic Cancer treatment across the world. 

Following are some of the significant interventions being studied: 

  1. Checkpoint inhibitors like Durvalumab, Tremelimumab, Nivolumab, Pembrolizumab, Atezolizumab, and others in Monotherapy  
  2. Checkpoint inhibitors in Combination Chemotherapy or Radiation 
  3. Checkpoint inhibitors in Combination therapy in Adjuvant or Neoadjuvant settings 

Immunotherapy – Cancer Vaccine Trials for Pancreatic Cancer 

Cancer Vaccines are developed against the Pancreatic Cancer tissue so that the body is primed to deliver an Immune Reaction against the Cancer cells. 

There are around thirty active Clinical Trials for evaluating innovative Cancer Vaccines for Pancreatic Cancer treatment across the world. 

Following are some of the significant interventions being studied: 

  1. Neoantigen DNA-based pancreatic cancer vaccine 
  2. Plasmid DNA pancreatic tumor cell vaccine 
  3. GVAX Pancreas vaccine 
  4. Dendritic Cell (mDC3/8) vaccine 

Targeted therapy Trials for Pancreatic Cancer 

Therapies are developed againsts Targets that are Proteins, Molecules or Genes that lead to the conversion of normal Pancreatic cells to Cancer cells. There are around ninety active Clinical Trials for evaluating innovative Targeted therapy approaches for Pancreatic Cancer treatment across the world. 

Following are some of the significant interventions being studied: 

  1. Targeted therapies alone or in combination in Adjuvant or Neoadjuvant settings
  2. Targeted therapies like Sunitinib, Erlotinib, SGT-53 (genetic therapy),and others in advanced pancreatic cancer
  3. Targeted therapies in Combination with Chemotherapy or Radiation in advanced pancreatic cancer 


How Oncoshot Can Help You?

Oncoshot uses an advanced algorithm to match your profile with an extensive and specialized database of Cancer Clinical Trials from across the world. The Search outcomes provide you with a list of highly relevant and meaningful Clinical Trial options to suit your particular Cancer case. Get started now by creating your profile.

 

REFERENCES [for further information] 

  1. National Cancer Institute at the National Institutes of Health 
  2. https://www.cancer.gov/types/pancreatic/patient/pancreatic-treatment-pdq#_194
  3. National Institutes of Health’s ClinicalTrials.gov https://www.clinicaltrials.gov/ 
  4. Pancreatic Cancer Action Network https://www.pancan.org/facing-pancreatic-cancer/treatment/ 
  5. American Society of Clinical Oncology [ASCO] https://www.cancer.net/cancer-types/pancreatic-cancer 
  6. American Cancer Soceity https://www.cancer.org/cancer/pancreatic-cancer/treating/by-stage.html  
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